G. Han, M. Tamaki, V. Hruby
Oct 1, 2001
Citations
2
Influential Citations
126
Citations
Quality indicators
Journal
The journal of peptide research : official journal of the American Peptide Society
Abstract
Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides was achieved by using hydrogen chloride (4 m) in anhydrous dioxane solution for 30 min at room temperature. In the cases studied in our laboratory, this protocol provided superior selectivity to deprotect Nalpha-Boc groups in the presence of tert-butyl esters and tert-butyl ethers, including thio-tert-butyl ethers, but not phenolic tert-butyl ethers.