J. Kim, J. Park, S. Jang
Jan 4, 2021
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Influential Citations
5
Citations
Quality indicators
Journal
Allergy, Asthma & Immunology Research
Abstract
https://e-aair.org Nafamostat mesylate (NM) is a synthetic serine protease inhibitor originally developed as a therapeutic drug for pancreatitis. As it has an inhibitory action on platelet aggregation and coagulation factors, NM has commonly been used as an anticoagulant in continual renal replacement therapies.1 However, NM use is associated with adverse effects including hyperkalemia, agranulocytosis, and anaphylaxis.2,3 Here, we describe 4 cases of NM-induced anaphylaxis and review the adverse drug reactions caused by NM in the Korea Institute of Drug Safety-Korea Adverse Event Reporting System (KIDS-KAERS). This study was approved by the Institutional Review Board of the Hallym University Sacred Heart Hospital (No. 2020-05-012).