L. Allgén, Göran Holmberg, B. Persson
Jan 1, 1979
Citations
1
Influential Citations
13
Citations
Quality indicators
Journal
Acta Obstetricia et Gynecologica Scandinavica
Abstract
Abstract. Methenamine hippurate was administered orally as tablets or granules to healthy volunteers. Plasma concentrations of methenamine reached a maximum 1‐2 hours after a single dose and then declined with a half‐life of about 4 hours. The apparent distribution volume was similar to that of total body water. Renal clearance of methenamine was somewhat lower than that of creatinine. In cross‐over experiments over six days, methenamine recovered in the urine corresponded to about 80 per cent of the dose given per 12 hours, slightly lower values being obtained from granules than from tablets. The efficient renal elimination of methenamine was confirmed in similar studies on patients post‐operatively.