Xinwei He, Jiajia Tao, Xiaoqian Hu
Feb 22, 2016
Citations
0
Influential Citations
22
Citations
Journal
The Journal of organic chemistry
Abstract
An efficient, environmentally friendly and one-pot route to new 9-aryl/9-arylethynyl-2,3,4,9-tetrahydro-1H-xanthen-1-one derivatives from inexpensive starting materials has been developed. This method proceeded by a domino nucleophilic-substitution/intramolecular cyclization/dehydration sequence of propargylic amines/diaryl amines and 1,3-cyclohexanediones under the promotion of FeCl3, which involved the formation of two new σ (C-C and C-O) bonds in a single operation for the construction of novel tetrahydroxanthene skeletons in 68-95% yields.