P. Berntsson, E. Johansson, C. Westerlund
1987
Citations
0
Influential Citations
10
Citations
Quality indicators
Journal
Journal of cardiovascular pharmacology
Abstract
Several 3,5-pyridinedicarboxylic acid [4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-] esters, which are analogs to felodipine, were synthesized and tested for peroral activity and vascular selectivity. Structure-activity relationships demonstrate that felodipine has biological properties (selectivity and oral activity) close to the optimum for this class of compounds.