James F. Fries, Melvin C. Britton
Sep 1, 1973
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Influential Citations
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Journal
Arthritis and rheumatism
Abstract
Fenoprofen Calcium (Lilly, Compound 69323) is a new nonsteroidal analgesic and antiinflammatory drug proposed for the treatment of rheumatoid arthritis and allied conditions. In a controlled double-blind crossover study comparing 6 weeks of Fenoprofen therapy with 6 weeks of treatment with high-dose acetylsalicylic acid, the aspirin proved minimally more effective and substantially more toxic. Nine of 27 patients found Fenoprofen equal to aspirin, and 6 preferred it. Twelve patients preferred aspirin. The safety of the drug suggested by animal studies appears to be confirmed by these short-term studies in relatively small numbers of patients. It appears likely that Fenoprofen will provide a useful, although not dramatic, additional agent with which to manage the patient with rheumatoid arthritis.