W. White, S. Wong
Apr 1, 1985
Citations
0
Influential Citations
10
Citations
Quality indicators
Journal
Archives of general psychiatry
Abstract
To the Editor.— Trazodone hydrochloride is a triazolopyridine derivative that was released in 1981 as a nontricyclic antidepressant with antiserotonin activity. 1 Recent reports have suggested that trazodone may have more cardiotoxicity than was first believed. 2,3 Herein, we describe a patient who manifested atrial fibrillation after trazodone therapy was instituted. Report of a Case.— 78-year-old woman was admitted to the hospital for the repair of a uterine prolapse. Five years Previously, she had had a subendocardial myocardial infarction and subsequently manifested a pattern of chronic stable angina pectoris. Her antianginal medications were isorbide dinitrate and propranolol hydrochloride. On admission, the ECG showed a sinus rhythm with a PR interval of 0.21 s and left ventricular hypertrophy. Because of frequent crying episodes, confusion, and a sleep disorder, the patient was seen by a psychiatrist preoperatively and was placed on a regimen of 200 mg/day of trazodone hydrochloride in two