K. Madauss, R. Bledsoe, I. McLay
Dec 1, 2008
Citations
1
Influential Citations
48
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
The amino-pyrazole 2,6-dichloro-N-ethyl benzamide 1 is a selective GR agonist with dexamethasone-like in vitro potency. Its X-ray crystal structure in the GR LBD (Glucocorticoid ligand-binding domain) is described and compared to other reported structures of steroidal GR agonists in the GR LBD (3E7C).