T. Storz, R. Marti, R. Meier
Jun 25, 2004
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0
Influential Citations
22
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Journal
Organic Process Research & Development
Abstract
The first safe and efficient synthesis of the important building block 2-amino-8-hydroxyquinoline (1) is described. Starting from the readily available N-oxide 3 of the cheap bulk chemical 8-hydroxyquinoline (2), the target compound is obtained in a two-step one pot procedure in good overall yield (53−66%) and purity (>98%) on a kilogram scale without chromatography.