D. Demong, Robert M. Williams
Mar 25, 2002
Citations
0
Influential Citations
7
Citations
Journal
Tetrahedron Letters
Abstract
The first asymmetric synthesis of (2S)-, and (2R)-amino-3,3-dimethoxypropanoic acid (α-formylglycine dimethylacetal) has been achieved in two steps and 91% overall yield. The key step involved the quenching of a chiral glycine titanium enolate with trimethyl orthoformate.