Xiaojun Huang, Jiang Zhu, S. Broadbent
Mar 24, 2010
Citations
1
Influential Citations
23
Citations
Journal
Tetrahedron Letters
Abstract
A simple and practical route for the asymmetric synthesis of (S)-4-(4-fluorophenyl)-1,4,5,6-tetrahydro-6-oxo-3-pyridinecarboxylic acid (1) is presented. The procedure comprises catalytic desymmetrization of a meso-anhydride using a chiral thiourea organocatalyst, followed by selective formylation and cyclization.