Chuangxing Guo, P. Fuchs
Mar 5, 1998
Citations
1
Influential Citations
61
Citations
Journal
Tetrahedron Letters
Abstract
The protected aglycone (21e-β) of the potent anti-tumor agent OSW-1 (1) was synthesized in 9 steps from 5-androsten-3β-ol-17-one (10) in 55% overall yield. Key reactions involve ene installation of the side chain, regio and stereoselective dihydroxylation and diastereoselective reduction of the C16 ketone.