K. Prasad, S. P. Reddy, K. Babu
2015
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0
Influential Citations
1
Citations
Journal
Helvetica Chimica Acta
Abstract
The first stereoselective synthesis of the cytotoxic polyketide (4R)-1-(3,5-dihydroxyphenyl)-4-hydroxypentan-2-one (1) was achieved from readily available propylene oxide and 3,5-dimethoxybenzyl alcohol. The synthesis involves Jacobsen's hydrolytic kinetic resolution (HKR) and Grignard reaction as key steps.