M. Fujii, K. Egawa, Y. Hirai
2009
Citations
0
Influential Citations
3
Citations
Journal
Heterocycles
Abstract
- Methylophiopogonanone B, a constituent of Ophiopogonis tuber, found to be a potent inhibitor of hypoxia induced factor-1α (HIF-1α) activity, was synthesized from 2,4,6-trihydroxy-3,5-dimethylacetophenone in 57% yield. The synthetic methylophiopogonanone B inhibited the reporter activity at 3 to 10 μg/mL.