G. Nagalatha, Siva Ganesh Narala, A. Narsaiah
Jul 1, 2018
Citations
0
Influential Citations
4
Citations
Journal
SynOpen
Abstract
Abstract An efficient protecting-group-free synthesis of tumonoic acid A and its derivatives has been accomplished. The synthesis started from commercially available n-octanal and employs the magnesium chloride catalysed anti-aldol reaction under the Evans protocol as the key step. Ethyl tumonoate A is a new tumonoic acid derivative with anti-inflammatory activity and inhibitory activity towards calcium oscillations in neocortical neurons.