Y. Ye, H. Koshino, J. Onose
Sep 12, 2007
Citations
0
Influential Citations
27
Citations
Journal
Organic Letters
Abstract
Vialinin A, a powerful inhibitor (IC50 90 pM) of TNF-α production, was synthesized from sesamol in 11 steps with 28% overall yield. The key reactions include a double Suzuki coupling of electron-rich aryl triflate with phenylboronic acid and an oxidative deprotection of bis-MOM ether. In addition, the related synthetic studies also suggest the necessity for structural revision of ganbajunin C, a positional isomer of vialinin A.