P. Clark, M. Poliakoff, A. Wells
Dec 10, 2007
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0
Influential Citations
34
Citations
Journal
Advanced Synthesis & Catalysis
Abstract
The hydrogenation of complex pharmaceutical intermediate, rac-sertraline imine has been optimized as a continuous flow process utilizing a palladium/calcium carbonate (Pd/CaCO 3 ) catalyst and hydrogen in supercritical carbon dioxide (scCO 2 ). Superior levels of selectivity were obtained in the flow system possibly attributable to the heat transfer properties of scCO 2 which help to remove excess heat from the catalyst surface.