Cui Hua-l
2013
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Journal
Journal of Northwest University
Abstract
A new method was established to the determination of Tosufloxacin Tosylate(TFLX) tablets.In the colorimetric cube of 10 mL,the Tb3+ solution,pH = 5.00 NaAc-HAc buffer solution,a certain amount of TFLX were added successively,diluted with distilled water to the scale,fluorescence intensity were determined at the emission wavelength of 545 nm with model 960 fluorescence spectrophotometer.Results show that Terbium(III) reacts with TFLX to form a compound in the medium of HAc-NaAc with the pH 5.0,emitting characteristic fluorescence of terbium(III),the maximum excitation wavelength was 365nm and the maximum emission was 545nm.The linear range for the determination of TFLX was 1.3 × 10-8~ 2.7 × 10-6mol/L and the detection limit for TFLX was.9.1× 10-9mol/L,the relative standard deviations were 1.3% ~ 2.1% and the recoveries 98.5% ~ 101%.The method,with simplicity,rapidness and sensitivity,can be successfully applied to the determination of TFLX tablets.