Vivian S. Lin, Christopher J. Chang
Dec 1, 2012
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Influential Citations
232
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Quality indicators
Journal
Current opinion in chemical biology
Abstract
Hydrogen sulfide (H(2)S) has long been recognized as a toxic molecule in biological systems. However, emerging studies now link controlled fluxes of this reactive sulfur species to cellular regulation and signaling events akin to other small molecule messengers, such as nitric oxide, hydrogen peroxide, and carbon monoxide. Progress in the development of fluorescent small-molecule indicators with high selectivity for hydrogen sulfide offers a promising approach for studying its production, trafficking, and downstream physiological and/or pathological effects.