Masayori Hagimori, Naoko Mizuyama, Y. Tominaga
Feb 1, 2015
Citations
0
Influential Citations
24
Citations
Journal
Dyes and Pigments
Abstract
Abstract Novel, low-molecular-weight fluorescent sensors based on a pyridine–pyridone core structure, which functions as both the chelating part moiety for Zn 2+ and as the fluorophore, were investigated. The length of the methylene spacer between the phenyl ring and the 3-position of the pyridone ring greatly influenced the emission wavelength and intensity upon Zn 2+ binding. 5-Benzyl-4-(methylsulfanyl)-[2,2′-bipyridin]-6(1 H )-one ( 2 ) (MW = 308) with a methylene spacer of n = 1 showed good water solubility, a 30 nm bathochromic shift in its emission wavelength and an 18-fold fluorescence enhancement in response to Zn 2+ . In addition, fluorescence microscopy imaging showed that 2 could be used to detect Zn 2+ in living cells.