Thangaraj Anand, S. Ashok Kumar, S. Sahoo
Nov 1, 2018
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Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Abstract
In this communication, we have developed an optical chemosensor 2-amino N-(6-bromo-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzamide (NAPH) for selective detection of Al3+ by reacting 4-bromo-1,8-naphthalic anhydride with 2-aminobenzohydrazide. In (DMSO:H2O, 1:1, v/v) medium, the selective and specific nature of NAPH towards Al3+ was observed by the quenching along with a blue-shift in the absorption of NAPH at 465 nm that resulted in the distinct colour change from light brown to colourless. The selective complexation that occurred between NAPH and Al3+ was investigated by 1H NMR and DFT methods. Under similar conditions, the weakly fluorescent receptor NAPH showed a distinct fluorescence enhancement at 555 nm in the presence of Al3+ among the other tested metal ions and anions. The NAPH·Al3+ complex formation is reversible upon addition of strong chelating agent EDTA. The receptor NAPH can be applied to detect Al3+ down to 2.9 μM without any interference from other tested metal ions. In addition, the receptor NAPH was successfully applied to detect Al3+ in live HeLa cells.