W. Scott
Mar 1, 1968
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Journal
Radiology
Abstract
As early as 1949, sodium fluoride was used experimentally in the treatment of leukemia. Intravenous doses of 600 mg showed a definite cytotoxic effect as evidenced by destruction of cells in twenty-eight to forty-eight hours, and a review of 70 cases in which sodium fluoride was given experimentally failed to reveal any systemic toxicity or parenchymatous damage (2). Over the past few years, reports have appeared on the treatment of osteoporosis (12), Paget's disease of bone (10), osteogenesis imperfecta (1), and multiple myeloma (5). The only symptoms of toxicity mentioned have been epigastric pain (produced by the formation of hydrofluoric acid and controlled with aluminum hydroxide, calcium carbonate, or enteric-coated capsules) and joint pain—probably the exacerbation of previously symptomatic degenerative arthritis. Inadvertent ingestion of sodium fluoride concentration greater than 10 ppm will eventually produce skeletal fluorosis. Calenoff (3) described a case of advanced skeletal fluorosis but no ...