S. Fustero, Antonio Simón-Fuentes, Ó. Delgado
2014
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Abstract
The synthesis of fluorine containing pyrazoles has been boosted in the past decades due to the interesting properties that confer these building blocks in pharmaceutical and agricultural active ingredients. There are two main methods for the synthesis of fluorine-containing organic compounds, namely, the direct replacement of an atom or functional group such as diazo, hydroxyl, halogen or hydrogen by fluorine, and the modification of fluorine-containing building blocks. In the case of fluorinated pyrazoles the latter approach is the most commonly applied. This chapter deals primarily with the pivotal procedures that allow the preparation of fluoro- and fluoroalkyl- pyrazoles. Their benzocondensed derivatives, indazoles, have been studied to a much lesser extent. The fundamental applications of this class of compounds in different fields are also discussed.