T. Pages, B. Langlois, D. Bars
Feb 1, 2001
Citations
0
Influential Citations
17
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract We propose here a new methodology to prepare 3-fluoro-α-methylphenylalanine in which fluorine is introduced at the end of the synthesis, on an elaborated substrate bearing a triazeno substituent which is decomposed by triflic acid in the presence of fluoride anions (yield=31% versus 19 F − ). As 18 F − cannot be available free of other basic anions, this technique has been modified and adapted with some success to the radiosynthesis of [ 18 F ]-3-fluoro-α-methylphenylalanine.