Toshiki Tajima, H. Ishii, T. Fuchigami
Jul 16, 2001
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Anodic fluorination of 2-cyano-1-methylpyrrole using Et 3 N·2HF in an undivided cell provided the corresponding 5-fluoropyrrole and 2,5,5-trifluoro-1-methyl-3-pyrrolin-2-carbonitrile while the use of Et 3 N·3HF afforded selectively the latter product, which was readily hydrolyzed to isolable 5,5-difluoro-1-methyl-3-pyrroline-2-one. This is the first report of successful anodic fluorination of a pyrrole derivative.