S. Higashiya, Takayuki Sato, T. Fuchigami
Feb 2, 1998
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0
Influential Citations
18
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Anodic regioselective fluorination of α -phenylsulphenylated ethyl acetates and acetonitriles of 1-naphthalene and 2-pyridine derivatives was investigated. 1-Naphthalene derivatives were selectively fluorinated at the α -carbon using Et 3 N·3HF/CH 3 CN in high yields while those devoid of an α -phenylsulphenyl group gave non-regioselectively polyfluorinated products. On the contrary, α -phenylsulphenylated 2-pyridine derivatives gave the corresponding α -fluoro compounds in low yields in CH 3 CN. The fluorinated products were obtained in much better-yields in DME. Moreover, their yields were significantly improved by the addition of Ph 2 S.