K. Makino, H. Yoshioka
Jun 1, 1988
Citations
0
Influential Citations
37
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract Fluorination of ethyl 1-methylpyrazole-4-carboxylate ( 1a ) and its 3-chloro analogue ( 1b ) with poly(hydrogen fluoride)-pyridine-triethylamine complex under electrolytic anodic oxidation yielded new ethyl 1-methyl-5-fluoropyrazole-4-carboxylate ( 2a ), ethyl 1-fluoromethyl-5-fluoropyrazole-4-carboxylate ( 3a ) and their 3-chloro analogues ( 2b ) and ( 3b ). Major factors controlling selectivities and yields for the fluorinated pyrazole-4-carboxylates are described. Selective fluorination of common organic carbonyl compounds or N-heterocycles at the activated carbon atom(s) under