K. Makino, H. Yoshioka
May 1, 1987
Citations
0
Influential Citations
13
Citations
Journal
Journal of Fluorine Chemistry
Abstract
Abstract A new combination of methanesulfonyl fluoride and cesium fluoride as modified with 18-crown-6 was demonstrated to be the best for selective fluorination of various benzyl alcohols via nucleophilic substitution. As extended applications of this procedure, ethyl 1-fluoromethylpyrazole-4-carboxylate ( 6 ) and N-fluoromethylphthalimide ( 12 ) have been synthesized in high yields from the corresponding alcohol ( 4 ) and chloride ( 11 ) respectively.