F. Anuar, M. Whiteman, M. Bhatia
Nov 1, 2006
Citations
0
Influential Citations
15
Citations
Quality indicators
Journal
Inflammation Research
Abstract
Abstract.ObjectiveFlurbiprofen and nitroflurbiprofen were evaluated in a caecal ligation puncture (CLP) model of septic shock in the rat.Methods and ResultsCLP (12 h) reduced blood pressure (72.5 ± 1.0 mm Hg c. f. 101.0 ± 3.6 mm Hg, P < 0.05), and increased plasma NOx (153.0 ± 11.5 μM c. f. 36.2 ± 3.2 μM, P < 0.05), IL-1β (534.0 ± 93.1 pg/mL c. f.; 9.6 ± 9.6 pg/mL, P < 0.05), TNF-α (88.0 ± 13.6 pg/mL, P < 0.05), inflammatory damage in lung and liver, and mortality. Both flurbiprofen (21 mg/kg, p. o.) and nitroflurbiprofen (30 mg/kg, p. o.) prevented the fall in blood pressure (e. g. 80.4 ± 2.1 mm Hg and 79.8 ± 1.2 mm Hg respectively, 12 h, P < 0.05), reduced organ damage and prolonged survival. Nitroflurbiprofen (but not flurbiprofen) increased plasma NOx and reduced plasma TNF-α concentration at all time points (except 1 h). Neither drug affected plasma IL-1β-levels.ConclusionsThese results suggest a protective effect of flurbiprofen and nitroflurbiprofen in septic shock.