G. Shapiro, R. Swoboda, U. Stauss
Jun 21, 1994
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An Fmoc based solid phase method for the synthesis of phosphoserine peptides has been developed which is amenable to standard protocols on automated synthesizers. The serine residue to be phosphorylated is protected with a t-butyldimethylsilyl group which is selectively removed from the resin bound protected peptide. On resin phosphorylation and final deprotection/cleavage are performed in standard fashion to yield serine phosphopeptides of significant length and complexity.