Meng Xianjun
2013
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Quality indicators
Journal
Food Science
Abstract
Objective: To evaluate the safety of eleutheroside,and to provide scientific support for the reasonable utilization and development of eleutheroside.Methods: According to the national standard procedures and methods in food safety and toxicological evaluation,a series of toxicological studies on the ingestion of eleutheroside were conducted,which included acute toxicity,genetic toxicity and subacute toxicity tests.Results: For acute toxicity,the maximum tolerated dose(MTD) was higher than 20 g/kg.The results of Ames test,mouse bone marrow micronucleus test and mouse sperm abnormality test were negative.After 30 d of feeding,rats showed no significant difference in body growth,organ development or histological observation.Conclusion: Eleutheroside is actually non-toxic with no genetic toxicity.No adverse effect of eleutheroside at 20 g/kg has been observed during trails for 30 d.