S. Tripathy, and Richard LeBlanc, T. Durst
Nov 16, 1999
Citations
0
Influential Citations
41
Citations
Journal
Organic Letters
Abstract
The generation of benzyne from iodobenzene with lithium tetramethylpiperidide in THF at −40 °C in the presence of lithium amides and ester enolates leads to mixtures in which 2-substituted iodobenzenes are often the major products. These products are obtained by iodine transfer from iodobenzene to the intermediate 2-lithioaromatics. The transfer of iodine occurs via a hypervalent iodine (ate) complex.