Brian W. Moran, P. T. Kenny
Aug 2, 2012
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0
Influential Citations
2
Citations
Journal
Synthetic Communications
Abstract
Abstract 4-N-Arylamino-1-butanol derivatives are produced via a palladium-catalyzed tetrahydrofuran ring-opening reaction. This reaction occurs during the reduction of aromatic nitro groups with polymethylhydrosiloxane (PMHS) and potassium fluoride in the presence of hydrogen peroxide. This represents a novel route for the synthesis of 4-N-arylamino-1-butanols. GRAPHICAL ABSTRACT