Gidget C Tay, Michael R Gesinski, Scott D Rychnovsky
2013
Citations
0
Influential Citations
15
Citations
Journal
Organic letters
Abstract
A new tetrahydropyranone synthesis has been developed that leads to cis-2,6-disubstituted 3,3-dimethyltetrahydropyran-4-one rings by condensation of an aldehyde and a hydroxy silyl enol ether. The reaction works with a variety of aldehydes to produce the tetrahydropyranone products in moderate to high yields. This new method was applied to the enantioselective synthesis of cyanolide A and its aglycone.