D. P. Aysola, M. Gibson
Feb 1, 1977
Citations
0
Influential Citations
5
Citations
Journal
Canadian Journal of Chemistry
Abstract
Syntheses of 1-o- and 1-m-chlorobenzoylisoquinolines are described, (a) from 2-benzoyl-1,2-dihydroisoquinoline-1-carbonitrile and the appropriate chlorobenzaldehyde, and (b) from 2-o- and 2-m-chlorobenzoyl-2-dihydroisoquinoline-1-carbonitrile. Treatment of either ketone with potassamide - potassium tert-butoxide in ammonia gives N-(1-isoquinolinyObenzamide. The mechanism of this reaction is discussed.