T. Ibata, Yasushi Isogami
Feb 1, 1989
Citations
0
Influential Citations
12
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
The BF3-catalyzed reaction of substituted α-diazoacetophenones with chloroacetonitrile gave 5-aryl-2-chloromethyloxazoles (3) in high yields. Methyl p-nitrophenyldiazoacetate also yielded 2-(chloromethyl)-5-methoxy-4-(p-nitrophenyl)oxazole. The nucleophilic substitution of 3 with primary, secondary, and tertiary amines afforded the corresponding secondary amines, tertiary amines, and quaternary ammonium salts bearing a 2-oxazolylmethyl group.