A. Klutch, W. Levin, R. Chang
Sep 1, 1978
Citations
0
Influential Citations
26
Citations
Quality indicators
Journal
Clinical Pharmacology & Therapeutics
Abstract
Conjugates of 3‐methylthio‐4‐hydroxyactanilide were found in the urine of dogs and humans treated with phenacetin (4‐ethoxyacetanilide) or acetaminophen (4‐hydroxyacetanilide). About 1% to 3% of the administered dose was excreted as this thiomethyl metabolite after administration ofphenacetin or acetaminophen to dogs. An average of0.39% ofthe dose was excreted in the urine as 3‐methylthio‐4‐hydroxyacetanilide conjugates after administration of phenacetin to several subjects, and an average of 0.66% of the dose was excreted as this metabolite in the urine after administration of acetaminophen to humans. The possibility that the thiomethyl metabolite is derived from a mercapturic acid conjugate or an N‐hydroxy derivative of phenacetin or acetaminophen is discussed.