B. H. T. Miles
Jun 1, 1961
Citations
0
Influential Citations
57
Citations
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abstract
The crystalline hydroper chloratel of III was used. The crystalline hydroiodide (called the methiodide by Hilbert because of its method of preparation) of IV and a sulfuric acid solution of IV (pH 2) were both measured and gave the same spectrum. reported that the product of the reaction of diazomethane with triacetylinosine was 1-methylinosine but made little serious attempt to purify or characterize the product. It has now been found that the reaction product, after ether precipitation as described, contains the 6-methoxy and 1-methyl derivatives as well as other substances. Pure 1-methylinosine has been obtained by column chromatography of the reaction mixture and found to be a crystalline substance of mp 209-210o, X max = 251 in H20. Details of the purification and characterization will be published at a later date.