H. Chaudhary, S. Saini, Gurpreet Singh
Sep 15, 2012
Citations
2
Influential Citations
9
Citations
Quality indicators
Journal
Journal of Drug Delivery and Therapeutics
Abstract
To treat allergic disorders on long term therapy needs plasma concentration of drug in better manner. This was achieved by formulating the drug in controlled release pattern. Fexofenadine hydrochloride is almost completely absorbed from the gastro-intestinal tract following oral administration,but bioavailability is reported to be only about 45% due to hepatic first-pass metabolism. The present study aims to prepare Transdermal patch of Fexofenadine hydrochloride.Preparation of transdermal patches of Fexofenadine hydrochloride using polymers: Hydroxypropyl methyl cellulose, Ethyl cellulose plasticized with Glycerol. The patches were evaluated for various parameters like Thickness, Water-Vapor Permeability, Tensile Strength, Drug Content,Diffusion and Dissolution studies. Prepared patches exhibited Zero Order Kinetics and the permeation profile was matrix diffusion type. In-vitro release study of Fexofenadine hydrochloride transdermal patch shown release of drug 79 % at 24 h and also follows zero order kinetics release pattern. Keywords : Fexofenadine Hydrochloride, Ethyl cellulose, Hydroxypropyl methyl cellulose, In-vitro.