Sanjesh G. Rathi, JayKumar G. Chaudhari
Jul 15, 2021
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Quality indicators
Journal
International Journal of Pharmaceutical Sciences Review and Research
Abstract
The present research work done with an objective of preparation and evaluation of floating tablets of Tofacitinib Citrate drug with Hydroxy propylene methyl cellulose (HPMC), Polyox N-60K, Carbopol 934 P and Guar gum polymers. Floating tablets were based on effervescent approach using sodium bicarbonate a gas releasing agent. Direct compression method was used in present study for preparation of tablets. Effect of polymers was evaluated by studying drug release and floating time. In-vitro drug release profile indicates that sustained nature increased by increasing the concentration of polymer. The formulation containing Polyox N-60K and Carbopol 934 P in combination was optimized as it showed drug release up to 12hrs. Optimized formulation F18 was found stable during stability condition up to 1 month.