Raghavendra Rao, Suryakar V
2010
Citations
0
Influential Citations
35
Citations
Quality indicators
Journal
International journal of pharma and bio sciences
Abstract
The montelukast is a leukotrine receptor antagonist (LTRA) used for the maintenance treatment of asthm a, chronic asthma attacks and to relieve symptoms of s easonal allergies. Because of poor bioavailability of montelukast sodium by oral route, there is a need t o increase its bioavailability by formulating it in to buccal dosage forms. Hence, montelukast sodium is a suita ble drug for buccal dosage forms and may provide a b tter therapeutic profile than oral route. In the present research work, montelukast sodium buccal patches w re prepared by using hydrophilic and hydrophobic polym ers. Buccal patches were characterized for number o f parameters like physical appearance and surface tex ture, weight uniformity, thickness, folding enduran ce, swelling index, surface pH, drug content uniformity , n vitro residence time, bursting strength, drug–excipients interaction study, and in vitro drug release study. All the patches were uniform a nd translucent, having good strength, and smooth surface. The thickness of the prepared patches was in the range of 0.266 to 0.326 mm. Folding endurance of all prepared patches was > 250 . The results of swelling index between the range of 30.03 44.27 %, and the surface pH was in the range pH o f buccal region. The results of drug content were i n the prescribed range. The i n vitro residence time for all the patches is in between 3. 20 5.59 hrs. The Bursting strength of patches is in the range of 4.166 to 5.7 33 Kg/cm. In vitro release studies were conducted for montelukast loaded patches exhibited drug release i n the range of 68.83 92.22 % in 8 hrs. FT-IR stud ies revealed that, there was no interaction between dru g and excipients used. Release of montelukast from all patches followed zero order and mechanism was diffu sion rate limited. Finally it can be concluded that F3 and F6 are the best formulation.