S. Schneller, J. May
Sep 1, 1978
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Influential Citations
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Journal
Journal of Heterocyclic Chemistry
Abstract
The synthesis of a number of 8-substituted- and 3-methyl-8-substituted-.s-triazolo[4,3-a]-pyrazines as model molecules for an isomer of formyein (i.e., 8-amino-3-(β-D-ribofuranosyl)-s-triazolo[4,3-a ]pyrazine (2)) and some of its derivatives (including aglycone) is reported. The C-8 subslituents include amino (3a and 4a), chloro (3b and 4b), hydroxy (as the 8-ones 8a and 9a), mercapto (as the 8-thiones 8c and 9c), hydroxylamino (3e and 4e), selenoxy (as the 8-selenones 8d and 9d), metlioxy (3g and 4g), and thiomethoxy (3h and 4h). Also described are 7-methyl-s-triazolo[4,3-a]pyrazin-8(7H) one (8b) and its 3-methyl derivative (9b) together with imidazo[1,2-g]-s-triazolo[4,3-a]pyrazine (10a) and its 3-methyl derivative (10b). Complete spectral data for all of these molecules is presented.