M. S. Abaee, Somaye Cheraghi
Dec 16, 2013
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0
Influential Citations
2
Citations
Journal
Arkivoc
Abstract
In the presence of water and triethylamine, a four-component process involving ethyl cyanoacetate, an -methylene carbonyl compound, a primary or a secondary amine, and elemental sulfur leads to efficient room-temperature formation of 2-amino-3-carboxamide derivatives of thiophene in short time periods. The products, which precipitate from the reaction mixtures, are easily obtained by simple filtration and recrystallization from ethyl acetate/hexanes.