Subbareddy V. Chitreddy, Sumathi Shanmugam
Oct 1, 2017
Citations
1
Influential Citations
15
Citations
Journal
Journal of Molecular Liquids
Abstract
Abstract A novel 4 H -chromene-3-carboxamide derivatives were synthesized from a multicomponent reaction between 2-hydroxybenzaldehyde, acetoacetanilide, and 4-hydroxycoumarin under solvent free conditions in the presence of ceric ammonium nitrate (CAN) via Knoevenagel-Michael reaction. In this work, we attempted and developed several amendments under solvent-free conditions to obtain the biologically important 4 H -chromene-3-carboxamides and characterized by NMR, HR-MS and UV–Vis spectroscopy analysis. The solvatochromic properties of compounds 4a – l was studied with solvents of increasing order of polarity. A series of 4 H -chromene-3-carboxamides 4 ( a – l ) and their antibacterial activities against Gram positive and Gram negative organisms was investigated using agar well technique. In the in vitro assay, the compounds 4k and 4l (9.3 μg/mL) showed promising antibacterial activity compared to ampicillin (standard). The compounds 4 ( a – l ) were studied for their in vitro antioxidant (DPPH method) activity, 4d , 4h , 4k , and 4l compounds showed strong antioxidant activity with IC 50 values of 1.39, 1.33, 1.26 and 1.10 μg/mL when compared to ascorbic acid (standard).