A. Commarieu, W. Hoelderich, J. Laffitte
May 31, 2002
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0
Influential Citations
52
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Journal
Journal of Molecular Catalysis A-chemical
Abstract
The Fries rearrangement of phenyl acetate for the paracetamol process is usually performed in hydrofluoric acid (HF). We have optimized this reaction with methane sulfonic acid (MSA), a strong, stable and biodegradable acid, to give para-hydroxyacetophenone with high conversion and selectivity (up to 92% of para-isomer and 8% of ortho-isomer at 100% conversion).