B. Patil, Sachinkumar K. Shinde, Ashutosh A. Jagdale
Sep 8, 2021
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0
Influential Citations
11
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Journal
Research on Chemical Intermediates
Abstract
A transition metal/ligand/additive/promoter-free synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones and the Biginelli-like synthesis is carried out in a natural acidic medium of Averrhoa bilimbi extract (ABE) with cleaner and facile approach smentioned here. The isoxazol-5(4H)-ones and 11-acetyl-2-methyl-5,6-dihydro-2H-2,6-methanobenzo[g][1,3,5]-oxadiaazocin-4(3H)-ones are synthesized, respectively, under aerobic conditions at room temperature and at reflux temperature of ethanol. This eco-friendly and economically cheap, non-toxic acidic catalytic media is obtained from the renewable resource, and its dynamic phase is confirmed by the optical microscopy, DLS technique, and with critical micelle concentration (c.m.c.) measurements. The notable advantages are excellent yields of the obtained products, versatility in handling substrates, reuse of the catalyst, use of no hazardous organic solvents, and minimization of waste or side products. So, the reported procedure is simple, evergreen, and a sound alternative to the existing protocols for isoxazol-5(4H)-one synthesis and for Biginelli-like synthesis as well.