P. Scott, X. Shao
Jun 17, 2010
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0
Influential Citations
30
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A General Electric Medical Systems (GEMS) Tracerlab FXFN fluorine-18 synthesis module has been reconfigured to allow rapid (45 min), fully automated production of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) using the established three-step, one-pot synthesis procedure. Purification is by sep-pak only and [18F]SFB is routinely obtained in 38% non-decay corrected yield,>1 Ci/µmol specific activity, and >95% radiochemical purity (n=20). Moreover, this report includes our preliminary research efforts into improving peptide coupling reactions with [18F]SFB using microwave-enhanced radiochemistry. Reaction times can be reduced by>90%, when compared with traditional thermal reactions, with no significant effect on radiochemical reaction yield. Copyright © 2010 John Wiley & Sons, Ltd.