L. Ping
2003
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Journal of China Pharmaceutical University
Abstract
AIM:To investigate the antiasthma mechanism of five fritillariae alkaloids, named as vertinine, verticinone, imperialine, imperialine 3 β D glucoside and puqietinone. METHOD:Observe the antimuscarinic effects of the five alkaloids on the carbachol precontracted guinea pig tracheal strips in vitro , and calculate their pA 2 values. RESULT:All of the five alkaloids can shift right the concentration response curves of carbachol. Using the Schild procedure, the pA 2 values of the five alkaloids are 6 91, 6 73, 7 18, 7 03 and 6 52, respectively.