J. N. Singh, B. Setty, S. R. Chowdhury
Jun 1, 1970
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Influential Citations
10
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Quality indicators
Journal
Contraception
Abstract
Abstract Adult male rats were injected with estradiol dipropionate at the rate of 0.1, 1.0, 5.0, 50.0 and 100.0 μg daily for 15 or 30 days. Doses lower than 5 μg had no effect on spermatogenesis and fertility, but higher doses caused spermatogenic arrest and inhibition of libido. The minimum effective dose was found to be 5 μg/15 days which caused 100% reduction in fertility without disturbing spermatogenesis or libido. However, when the treatment period was extended for 30 days varying degrees of spermatogenic interruption and loss of libido were recorded. The mechanism of antifertility action is discussed.