David Montoir, Alain Tonnerre, M. Duflos
Mar 1, 2014
Citations
0
Influential Citations
14
Citations
Journal
European Journal of Organic Chemistry
Abstract
A practical synthesis of 7-chloro-3-iodo-1-methyl-1,6-naphthyridin-2(1H)-one is described that starts from 2-chloro-4-(methylamino)nicotinaldehyde. The dihalo compound then undergoes sequential, site-selective Suzuki–Miyaura cross-coupling reactions to afford highly functionalized 1,6-naphthyridones in good yields.